A teenage girl has died in hospital four days after a two-car smash in Carlton on the weekend.

The 16-year-old Brunswick girl and four others were injured when a Volkswagen Passat hit an Alfa Romeo – which the teenager was a passenger in – and caused the car to spin out of control into two pedestrians on Lygon Street about noon on Saturday.

The girl was rushed to hospital with critical injuries, but police said she had died on Wednesday afternoon.

The man behind the wheel of the Volkswagen, Gulet Ahmed, 40, was charged on Sunday after police said he was allegedly driving erratically in the area before the crash.

Two other occupants in the Alfa Romeo, a 61-year-old man and a 53-year-old woman, both from Brunswick, were taken to hospital with non-life-threatening injuries.

The two pedestrians hit in the incident – both from Carlton and in their early 40s – were also taken to hospital, but with non-life-threatening injuries.

Ahmed has been charged with dangerous driving causing serious injury, negligently causing serious injury and methylamphetamine possession.

He was remanded in custody to appear in court at a later date.

With AAP

Police investigate the cause of the crash in Carlton on Saturday.Credit:Nine News

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